Omicron变异株XBB.1.16流行情况和病原学特征Research progress on the epidemic and pathogenic characteristics of Omicron variant XBB.1.16
王楠,董泽丰,屠博文,陈曦,陈嘉欣,王达,李鑫娜,许果,冯欢欢,何芳,于翔翔,吴海鸥,严炳清,马广源,朱立国,付建光
摘要(Abstract)：
奥密克戎变异株XBB.1.16于2023年1月9日在印度首次被发现，其病毒表面刺突(Spike, S)蛋白的E180V、T478R、F486P突变增加了病毒的传播力、致病性和免疫逃逸能力，使得在美国、印度等国家的新冠病例数激增。2023年4月17日，世界卫生组织指定XBB.1.16为感兴趣的变异株(variant of interest, VOI),但未观察到疾病严重程度的增加或额外的公共健康风险，其全球评估风险较低。本文通过文献阅读和数据库检索分析，对XBB.1.16流行情况和病原学特征进行总结，为新冠病毒防控策略的制定及疫苗、药物的研究提供科学参考。
关键词(KeyWords)： 新型冠状病毒;奥密克戎;XBB.1.16;变异株;流行特征;病原学特征;免疫逃逸;风险研判
基金项目(Foundation): 江苏省科技厅重点研发计划(BE2023601);; 江苏省卫生健康委科研重点项目(DX202301);; 江苏省333重点行业领域人才项目
作者(Author): 王楠,董泽丰,屠博文,陈曦,陈嘉欣,王达,李鑫娜,许果,冯欢欢,何芳,于翔翔,吴海鸥,严炳清,马广源,朱立国,付建光
DOI: 10.13668/j.issn.1006-9070.2023.03.001
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